Fernando Gómez-Pinilla, Ph.D. is a professor of neurosurgery
and physiological science at the University of California, Los Angeles,
and believes that appropriate changes to a person's diet can enhance
cognitive abilities, protect the brain from damage and counteract the
effects of aging.
Dr Gómez-Pinilla has been studying the effects of food on
the brain for years, and has now completed a review, just published in
Nature Reviews Neuroscience, that has analyzed more than 160 studies of
food's effect on the brain. He is also interested on the mechanisms by
which environmental factors affect neuronal health. His group has found
that trophic factors endogenous to the brain and spinal cord can be
induced by the practice of select behaviors. They have recently
reported that physical activity, learning, and nutritional factors
control neurotrophins in the brain. These findings opened the exciting
possibility that regulation of trophic factors by behavior can be a
pivotal mechanism by which specific experiences can impact the
structure and function of the CNS. It may account for the improvement
of CNS function after trauma provided by rehabilitative therapies. On
the contrary, it may explain the decay in function in aging or
degenerative diseases following a lack of stimulation.
These two avenues provide direction for his research program: 1) How
trophic factors induced by activity can help functional recovery
following brain and spinal cord trauma. They are using several exercise
models to boost the production of trophic factors in the brain and
spinal cord.
Their goal is to provide critical information to guide the design of
behavioral therapies for the reduction of the severity of insult or
disease, and to increase CNS function. 2) they are evaluating the
effects of lifestyle on trophic factor production, with resulting
effects on circuit remodeling, synaptic function, and cognition. He
believes that changes in trophic factor as a result of select
experiences can affect neuronal health with profound consequences for
cognitive function.